Thanks for your reply Medtner, a lot of usefull information!
I am not planning to extensively use autopilot, as you says, it would be a pity to put the hands off the yoke! Only when setting up the GPS or such.
Your experience with trimming in P3D is reassuring I have to say. Just to make sure, since it differs from the one of Ady, that we mean the same thing with realistic trimming : say you are level by holding the yoke in a certain position, rotating the trim wheel accordingly decreases the force needed to hold the position of the yoke, until no force is needed anymore. At this point the yoke remains in the same position whithout holding (the plane is trimmed).
Is it what you can achieve with the trim wheel in “hardware trim” mode?